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Created in January 2009 by virtue of the Executive Order 514: “Establishing the National Biosafety Framework Prescribing Its Implementation, Strengthening the National Committee on Biosafety of the Philippines, and for Other Purposes” dated 27 March 2006 to review application for contained used of Genetically Modified Organisms (GMOs).

The DOST BC together with the Biosafety Committees of the Department of Health, Environment and Natural Resources and Agriculture were established in order to enhance the existing biosafety framework so as to better respond to the challenges presented by further advances in modern biotechnology. These challenges include the rapid expansion of the use of modern biotechnology not only for scientific research but also for commercial releases and the growing concern over biotechnology's potential impacts on the environment, on human health as well as on social and cultural well-being. Moreover, there is also the need for the country to continuously comply with the administrative requirements set by the Cartagena Protocol on Biosafety, since the Protocol was entered into force in the Philippines on 3 January 2007.